Open AccessSynthesis and antibacterial activity studies of 2,4-di substituted furan derivatives
Author(s) -
Sireesha Malladi,
R. Venkata Nadh,
K. Suresh Babu,
P. Suri Babu
Publication year - 2017
Publication title -
beni-seuf university journal of basic and applied sciences /beni-suef university journal of basic and applied sciences
Language(s) - English
Resource type - Journals
eISSN - 2314-8543
pISSN - 2314-8535
DOI - 10.1016/j.bjbas.2017.08.001
Subject(s) - proteus vulgaris , antibacterial activity , escherichia coli , furan , bacteria , proteus , chemistry , streptococcus pyogenes , gram positive bacteria , gram , microbiology and biotechnology , organic chemistry , antimicrobial , biology , biochemistry , staphylococcus aureus , genetics , gene
2,4 disubstitiuted furan derivatives (8Aâ8M) were prepared from furan-4-carboxylic acid ethyl ester (1). Antibacterial activity of new 2,4 di substituted furan derivatives was studied against Gram (+) and Gram (â) bacteria. 8F, 8E, 8D and 8J were found to be effective against Gram (â) bacteria whereas, 8A and 8L were effective against Gram (+) bacteria. Least MIC value was found as 100 µg/ml against Escherichia coli (for 8D and 8F), and Proteus vulgaris (for 8E and 8F). Antibacterial activity is correlated with different substituents. Products exhibited better antibacterial activities especially towards Streptococcus pyogenes, Proteus vulgaris, and Escherichia coli. Keywords: Pathogens, Antibacterial activity, Structure-activity relationship, Disubstitiuted furans, Synthesi