Efficient synthesis of a novel series of indeno fused pyrido[2,3-d]pyrimidines using β-cyclodextrin-propyl sulfonic acid as an eco-friendly catalyst | Zendy

Prasanithiya Sudhan | Zendy; Majid Ghashang | Zendy; S. Sheik Mansoor | Zendy

Open Access

Efficient synthesis of a novel series of indeno fused pyrido[2,3-d]pyrimidines using β-cyclodextrin-propyl sulfonic acid as an eco-friendly catalyst

Author(s) -

Prasanithiya Sudhan,

Majid Ghashang,

S. Sheik Mansoor

Publication year - 2016

Publication title -

beni-suef university journal of basic and applied sciences

Language(s) - English

Resource type - Journals

eISSN - 2314-8543

pISSN - 2314-8535

DOI - 10.1016/j.bjbas.2016.11.004

Subject(s) - sulfonic acid , catalysis , chemistry , yield (engineering) , pyrimidine , cyclodextrin , uracil , aryl , condensation , organic chemistry , solvent , environmentally friendly , condensation reaction , reaction conditions , combinatorial chemistry , stereochemistry , materials science , dna , ecology , biochemistry , alkyl , physics , biology , metallurgy , thermodynamics

A simple and facile synthesis of 5-aryl-5,11-dihydro-1H-indeno[2′,1′:5,6]pyrido[2,3-d]pyrimidine-2,4,6-trione derivatives was accomplished by the one-pot condensation of aromatic aldehydes, 1,3-indandione and 6-amino uracil under solvent-free conditions in the presence of the catalyst, β-cyclodextrin-propyl sulfonic acid (β-CD-PSA). This method has the advantages of high yield, clean reaction, simple methodology, and short reaction time. The catalyst could be recycled and reused four times without significant loss of activity

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