Open AccessStudy of antimicrobial, analgesic wound healing and antioxidant activities of some newly synthesized oxychinolin derivatives and their characterization
Author(s) -
Jagannath Sahoo,
Sudhir Kumar Paidesetty
Publication year - 2015
Publication title -
beni-seuf university journal of basic and applied sciences /beni-suef university journal of basic and applied sciences
Language(s) - English
Resource type - Journals
eISSN - 2314-8543
pISSN - 2314-8535
DOI - 10.1016/j.bjbas.2015.08.001
Subject(s) - antimicrobial , benzoic acid , ampicillin , agar diffusion test , analgesic , antioxidant , chemistry , benzene , sulfonamide , pharmacology , antibiotics , organic chemistry , medicine , biochemistry , escherichia coli , gene
A series of aryl and heteroaryl substituted oxychinolin derivatives have been synthesized and spectral characterizations have been conducted with different modern analytical techniques. The antimicrobial activities of the novel synthesized oxychinolin analogs against different microbial strains have been screened by agar diffusion method. The compounds 4g and 4h were observed with significant antibacterial activity in comparison to reference antibiotic (ampicillin) against most of the bacterial pathogens. Compounds 4-((8-hydroxyquinolin-5-yl) diazenyl)-N-(5-methyl isoxazol-3-yl) benzene sulfonamide (4c), 4-((8-hydroxyquinolin-5-yl) diazenyl)-1, 5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (4g) and 2-((8-hydroxyquinolin-5-yl)diazenyl) benzoic acid (4h) showed zone of inhibition at MIC level 31.25 µg mL−1 against most of the organisms. The compounds 4g and 4h are observed with significant wound healing, analgesic and potential antioxidant activity