Open AccessEnhanced in vitro dissolution of Iloperidone using Caesalpinia Pulcherrima mucoadhesive microspheres
Author(s) -
Pradum Pundlikrao Ige,
Kapil M. Agrawal,
Upesh Patil
Publication year - 2015
Publication title -
beni-seuf university journal of basic and applied sciences /beni-suef university journal of basic and applied sciences
Language(s) - English
Resource type - Journals
eISSN - 2314-8543
pISSN - 2314-8535
DOI - 10.1016/j.bjbas.2015.02.004
Subject(s) - mucilage , mucoadhesion , particle size , chromatography , dissolution , solubility , materials science , microsphere , chemistry , drug delivery , drug carrier , chemical engineering , nanotechnology , organic chemistry , botany , engineering , biology
The aim of the present investigation was to improve the solubility and dissolution rate of Iloperidone. Microspheres containing Iloperidone were prepared by spray drying using mucilage extracted from seeds of Caesalpinia pulcherrima. The novelty of this work is that, the extraction of mucilage and its usage for preparation of drug loaded microspheres. The prepared microspheres were characterized by SEM, DSC, XRPD, FTIR, 1H-NMR, particle size, drug content, entrapment efficiency, in vitro dissolution and ex vivo mucoadhesion. Based on particle size, drug content, ex vivo mucoadhesive strength and in vitro drug release, the best formulation was optimized. Percent entrapment efficiency and mean particle size for optimized formulation was found to be 73.49 and 3.27 ± 1.23 μm, respectively. More precisely, mucilage of C. pulcherrima could be significant carrier of (drug and polymer ratio 1:5) microspheres for the development of oral drug delivery