Open AccessMicrowave assisted synthesis of some novel acetazolamide cyclocondensed 1,2,3,4-tetrahydropyrimidines as a potent antimicrobial and cytotoxic agents
Author(s) -
Karthikeyan Elumalai,
Mohammed Ashraf Ali,
Manogaran Elumalai,
Kalpana Eluri,
S. Srinivasan,
Sujit Kumar Mohanty
Publication year - 2014
Publication title -
beni-seuf university journal of basic and applied sciences /beni-suef university journal of basic and applied sciences
Language(s) - English
Resource type - Journals
eISSN - 2314-8543
pISSN - 2314-8535
DOI - 10.1016/j.bjbas.2014.02.003
Subject(s) - antimicrobial , cytotoxicity , thiourea , chemistry , urea , bacillus subtilis , acetazolamide , nuclear chemistry , in vitro , bacillus cereus , sulfonyl , escherichia coli , organic chemistry , combinatorial chemistry , biochemistry , bacteria , alkyl , biology , physiology , gene , genetics
A new series of some novel acetazolamide cyclocondensed 1,2,3,4-tetrahydropyrimidines was prepared by reacting of N-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]sulfonyl}-3-oxobutanamide with urea/thiourea and appropriate aldehyde in the presence of catalytic amount of laboratory made p-toluenesulfonic acid as an efficient catalyst. Confirmation of the chemical structure of the synthesized compounds (12a–n) was substantiated by TLC, different spectral data IR, 1H NMR, Mass spectra and elemental analysis were done. The synthesized compounds were evaluated for in-vitro antimicrobial and cytotoxicity against Bacillus subtilis, Escherichia coli and Vero cells. The titled compounds exhibited weak, moderate, or high in-vitro antimicrobial and cytotoxicity. Compounds 12c, 12d, 12g and 12h, exhibited potential antimicrobial and in-vitro cytotoxicity