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Boundary elements and nuclear organization
Author(s) -
Capelson Maya,
Corces Victor G.
Publication year - 2004
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/j.biolcel.2004.06.004
Subject(s) - chromatin , compartmentalization (fire protection) , biology , insulator (electricity) , scaffold/matrix attachment region , chia pet , microbiology and biotechnology , nucleus , function (biology) , cell nucleus , computational biology , genomic organization , genome , genetics , chromatin remodeling , gene , physics , biochemistry , optoelectronics , enzyme
Functional compartmentalization of eukaryotic genomes is thought to be necessary for the proper regulation of gene expression. Chromatin insulators or boundary elements have been implicated in the establishment of this compartmentalization, as they may be involved in creating independent chromatin domains. Recent advances in understanding the mechanisms of insulator function suggest a role for boundary elements in determining transcriptional identity of chromatin and in organizing chromatin into structural compartments within the nucleus. Insulators may thus be involved in setting up topological chromatin domains associated with particular transcriptional states.