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The nucleolus and transcription of ribosomal genes
Author(s) -
Raška Ivan,
Koberna Karel,
Malínský Jan,
Fidlerová Helena,
Mašata Martin
Publication year - 2004
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/j.biolcel.2004.04.015
Subject(s) - ribosome biogenesis , nucleolus , biology , ribosomal rna , ribosomal protein , ribosome , microbiology and biotechnology , genetics , biogenesis , computational biology , gene , rna , cytoplasm
Ribosome biogenesis is a highly dynamic, steady‐state nucleolar process that involves synthesis and maturation of rRNA, its transient interactions with non‐ribosomal proteins and RNPs and assembly with ribosomal proteins. In the few years of the 21st century, an exciting progress in the molecular understanding of rRNA and ribosome biogenesis has taken place. In this review, we discuss the recent results on the regulation of rRNA synthesis in relation to the functional organization of the nucleolus, and put an emphasis on the situation encountered in mammalian somatic cells.