Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2 | Zendy

OstareckLederer Antje | Zendy; Ostareck Dirk H. | Zendy

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Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

Author(s) -

OstareckLederer Antje,

Ostareck Dirk H.

Publication year - 2004

Publication title -

biology of the cell

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.543

H-Index - 85

eISSN - 1768-322X

pISSN - 0248-4900

DOI - 10.1016/j.biolcel.2004.03.010

Subject(s) - biology , heterogeneous nuclear ribonucleoprotein , heterogeneous ribonucleoprotein particle , messenger rna , translation (biology) , rna recognition motif , microbiology and biotechnology , ribonucleoprotein , rna binding protein , haematopoiesis , subfamily , cytoplasm , gene expression , rna , gene , genetics , stem cell

Summry— Studies on the post‐transcriptional regulation of gene expression in haematopoietic cells have uncovered that a subfamily of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. HnRNP K and hnRNP E1/E2 share a common structural motif, the hnRNP K homology (KH) domain, which provides a structural basis for mRNA binding. The KH‐domains are components of a modular system, which enables these proteins to engage in both, protein/nucleic acid and protein/protein interactions, the latter generating connectivity to cell signalling events. As components of different mRNA‐protein complexes, hnRNP K and hnRNP E1/E2 function in the control of mRNA translation and mRNA stability in haematopoietic cell differentiation.

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