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Subcellular distribution of the inositol 1,4,5‐trisphosphate receptors: functional relevance and molecular determinants
Author(s) -
Vermassen Elke,
Parys Jan B.,
Mauger JeanPierre
Publication year - 2004
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/j.biolcel.2003.11.004
Subject(s) - endoplasmic reticulum , biology , inositol trisphosphate receptor , inositol , subcellular localization , intracellular , microbiology and biotechnology , receptor , nucleus , gene isoform , cytoplasm , redistribution (election) , cell , mitochondrion , biochemistry , gene , politics , political science , law
The inositol 1,4,5‐trisphosphate receptor (IP 3 R) is an intracellular Ca 2+ channel that is for the largest part expressed in the endoplasmic reticulum. Its precise subcellular localization is an important factor for the correct initiation and propagation of Ca 2+ signals. The relative position of the IP 3 Rs, and thus of the IP 3 ‐sensitive Ca 2+ stores, to mitochondria, nucleus or plasma membrane determines in many cases the physiological consequences of IP 3 ‐induced Ca 2+ release. Most cell types express more than one IP 3 R isoform and their subcellular distribution is cell‐type dependent. Moreover, it was recently demonstrated that depending on the physiological status of the cell redistribution of IP 3 Rs and/or of IP 3 ‐sensitive Ca 2+ stores could occur. This indicates that the cell must be able to regulate not only IP 3 R expression but also its distribution. The various proteins potentially determining IP 3 R localization and redistribution will therefore be discussed.