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Introduction to chromosome dynamics in mitosis
Author(s) -
Watrin Erwan,
Legagneux Vincent
Publication year - 2003
Publication title -
biology of the cell
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 85
eISSN - 1768-322X
pISSN - 0248-4900
DOI - 10.1016/j.biolcel.2003.08.003
Subject(s) - biology , mitosis , chromatin , prophase , premature chromosome condensation , chromosome , chromosome segregation , cell cycle , control of chromosome duplication , genetics , microbiology and biotechnology , replication (statistics) , dna replication , dna , cell , gene , meiosis , virology
To ensure that the genetic information, replicated in the S‐phase of the cell cycle, is correctly distributed between daughter cells at mitosis, chromatin duplication and chromosome segregation are highly regulated events. Since the early 1980's, our knowledge of the mechanisms governing these two events has greatly increased due to the use of genetic and biochemical approaches. We present here, first, an overview of the replication process, highlighting molecular aspects involved in coupling replication with chromatin dynamics in mitosis. The second part will present the current understanding of chromosome condensation and segregation during mitosis in higher eukaryotes. Finally, we will underline the links that exist between replication and mitosis.