Umbelliferone: Sources, chemistry and bioactivities review | Zendy

Ofentse Mazimba | Zendy

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Umbelliferone: Sources, chemistry and bioactivities review

Author(s) -

Ofentse Mazimba

Publication year - 2017

Publication title -

bulletin of faculty of pharmacy cairo university

Language(s) - English

Resource type - Journals

eISSN - 2090-9101

pISSN - 1110-0931

DOI - 10.1016/j.bfopcu.2017.05.001

Subject(s) - umbelliferone , chemistry , coumarin , abts , bergapten , phenylpropanoid , resorcinol , radical , acetic acid , combinatorial chemistry , dpph , organic chemistry , antioxidant , psoralen , biochemistry , dna , enzyme , biosynthesis

Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent. It is synthesized using the Pechmann condensation reaction of resorcinol and formyl acetic acid. Biosynthetically it is synthesized using the phenylpropanoid pathway. Umbelliferone is a synthon for other coumarins and heterocycles with improved biological activities. In the Literature modest antibacterial and antifungal activities are reported with MIC values of 500â1000Â Î¼g/mL, but exhibited good E. coli anti-biofilm formation. Umbelliferone shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals. Other reported activities are anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities. Keywords: Umbelliferone, Anti-bacterial, Anti-tumor, Cytotoxicity, Synthesis, Biosynthesi

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