Open AccessUmbelliferone: Sources, chemistry and bioactivities review
Author(s) -
Ofentse Mazimba
Publication year - 2017
Publication title -
bulletin of faculty of pharmacy, cairo university /bulletin of faculty of pharmacy, cairo university
Language(s) - English
Resource type - Journals
eISSN - 2090-9101
pISSN - 1110-0931
DOI - 10.1016/j.bfopcu.2017.05.001
Subject(s) - umbelliferone , chemistry , coumarin , abts , bergapten , phenylpropanoid , resorcinol , benzothiophene , combinatorial chemistry , dpph , organic chemistry , psoralen , biochemistry , antioxidant , dna , enzyme , biosynthesis , thiophene
Umbelliferone is a 7-hydroxycoumarin that is a pharmacologically active agent. It is widely distributed within the Rutaceae and Apiaceae (Umbelliferae) families and is efficiently extracted using methanol. Umbelliferone is a fluorescing compound used as a sunscreen agent. It is synthesized using the Pechmann condensation reaction of resorcinol and formyl acetic acid. Biosynthetically it is synthesized using the phenylpropanoid pathway. Umbelliferone is a synthon for other coumarins and heterocycles with improved biological activities. In the Literature modest antibacterial and antifungal activities are reported with MIC values of 500â1000 μg/mL, but exhibited good E. coli anti-biofilm formation. Umbelliferone shows good inhibitions of DPPH, hydroxyl, superoxide anion and ABTS radicals. Other reported activities are anti-inflammatory, anti-hyperglycaemic, molluscicidal and anti-tumor activities. Keywords: Umbelliferone, Anti-bacterial, Anti-tumor, Cytotoxicity, Synthesis, Biosynthesi