Open AccessAntifungal and cytotoxic constituents from the endophytic fungus Penicillium sp.
Author(s) -
Ehab S. Elkhayat,
Asmaa Mohamed Goda
Publication year - 2017
Publication title -
bulletin of faculty of pharmacy, cairo university /bulletin of faculty of pharmacy, cairo university
Language(s) - English
Resource type - Journals
eISSN - 2090-9101
pISSN - 1110-0931
DOI - 10.1016/j.bfopcu.2017.03.001
Subject(s) - penicillium , plant use of endophytic fungi in defense , candida albicans , tyrosol , ethyl acetate , fungus , biology , botany , stereochemistry , chemistry , biochemistry , phenols
New mellein derivative; 4-methylmellein (1) along with five known compounds: 4-hydroxymellein (2) and 6-hydroxymellein (3), tyrosol (4), cervesterol (5), and stigmast-4-ene-3-one (6) were isolated from the ethyl acetate extract of the endophytic fungus Penicillium sp. isolated from the leaf of Senecio flavus (Asteraceae). Structures were established by 1D and 2D NMR, in addition to UV, IR and MS spectrometry. Compounds (3, 4 and 6) were isolated for the first time from the genus Penicillium. Compounds 1–4 showed antifungal activity against F. oxysporum and variable activities against A. flavus and the yeast C. albicans. Compounds 1–3 showed cytotoxic activity against MCF-7 cell line