Open AccessSynthesis and anti-mycobacterial evaluation of some new isonicotinylhydrazide analogues
Author(s) -
Maha A. Elhakeem,
Azza T. Taher,
Suzan M. AbuelMaaty
Publication year - 2015
Publication title -
bulletin of faculty of pharmacy, cairo university /bulletin of faculty of pharmacy, cairo university
Language(s) - English
Resource type - Journals
eISSN - 2090-9101
pISSN - 1110-0931
DOI - 10.1016/j.bfopcu.2014.11.001
Subject(s) - in vitro , isoniazid , minimum inhibitory concentration , mycobacterium tuberculosis , strain (injury) , chemistry , mycobacterium , combinatorial chemistry , tuberculosis , microbiology and biotechnology , stereochemistry , biology , biochemistry , medicine , pathology , anatomy
The synthesis of some new 3,4-disubstituted thiazolylideneisonicotinohydrazide derivatives 3a–k, 2-substituted thiazolidinylisonicotinamide derivatives 4a–d and pyrrolylisonicotinamide derivatives 5, 6 and 7 is described. The resulted compounds are evaluated for their in vitro antitubercular activity. The minimum inhibitory concentration (MIC) of compound 3g showed comparable in vitro activity to isoniazid against Mycobacterium tuberculosis H37Ra 7131 strain in concentration 9.77μg/mL