Open AccessAnticonvulsant activity of novel 1-(morpholinomethyl)-3-substituted isatin derivatives
Author(s) -
G. Saravanan,
V. Alagarsamy,
P. Dineshkumar
Publication year - 2014
Publication title -
bulletin of faculty of pharmacy, cairo university /bulletin of faculty of pharmacy, cairo university
Language(s) - English
Resource type - Journals
eISSN - 2090-9101
pISSN - 1110-0931
DOI - 10.1016/j.bfopcu.2014.02.001
Subject(s) - isatin , chemistry , anticonvulsant , combinatorial chemistry , organic chemistry , psychology , epilepsy , neuroscience
A variety of novel isatin derivatives 5a–5j and 6a–6j were synthesized and characterized by spectroscopic means and elemental analysis. The title compounds were investigated for antiepileptic activity using MES and scPTZ seizures tests. Neurotoxicity study was performed by the rotorod test. The relationship between the functional group variation and the biological activity of the evaluated compounds was discussed. Among the synthesized analogs, the most active one was 6f that revealed protection in MES at a dose of 30mg/kg (i.p.) after 0.5h and 4h. This molecule also provided protection in the scPTZ at a dose of 100mg/kg (0.5h) and 300mg/kg (4h)