Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt | Zendy

Camilia G. Michel | Zendy; Moshera M. ElSherei | Zendy; Wafaa T. Islam | Zendy; Amany A. Sleem | Zendy; Shaimaa R. Ahmed | Zendy

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Bioactivity-guided fractionation of the stem bark extract of Pterocarpus dalbergioides Roxb. ex Dc growing in Egypt

Author(s) -

Camilia G. Michel,

Moshera M. ElSherei,

Wafaa T. Islam,

Amany A. Sleem,

Shaimaa R. Ahmed

Publication year - 2013

Publication title -

bulletin of faculty of pharmacy cairo university

Language(s) - English

Resource type - Journals

eISSN - 2090-9101

pISSN - 1110-0931

DOI - 10.1016/j.bfopcu.2012.07.003

Subject(s) - genistin , fractionation , chemistry , traditional medicine , bark (sound) , gallic acid , anti inflammatory , chromatography , antioxidant , pharmacology , biochemistry , biology , medicine , ecology , daidzein , genistein , endocrinology

A bioactivity-guided investigation of the ethanolic extract (70%) of the stem bark of Pterocarpus dalbergioides Roxb. ex DC revealed that the butanol fraction possessed potent antihyperglycemic and anti-inflammatory activities at a dose of 100mg/kg b.wt. compared to metformin (150mg/kg b.wt.) and indomethacin (20mg/kg b.wt.) respectively. Two phenolic acids viz: gentisic (1) and gallic (3) acids and isoflavone genistin (2) were isolated for the first time from the studied plant adopting a bioactivity-guided fractionation. Identification of the isolated compounds was achieved using physical, chemical and spectroscopic data

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