Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease | Zendy

Prashamsa Koirala | Zendy; Su Hui Seong | Zendy; Hyun Ah Jung | Zendy; Jae Sue Choi | Zendy

Open Access

Comparative molecular docking studies of lupeol and lupenone isolated from Pueraria lobata that inhibits BACE1: Probable remedies for Alzheimer's disease

Author(s) -

Prashamsa Koirala,

Su Hui Seong,

Hyun Ah Jung,

Jae Sue Choi

Publication year - 2017

Publication title -

asian pacific journal of tropical medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.491

H-Index - 52

ISSN - 1995-7645

DOI - 10.1016/j.apjtm.2017.10.018

Subject(s) - lupeol , chemistry , ic50 , triterpene , docking (animal) , stereochemistry , enzyme , pueraria , biochemistry , in vitro , medicine , alternative medicine , nursing , pathology

To discover lead lupane triterpenoid's potential isolated from Pueraria lobata roots against β-site amyloid precursor protein cleaving enzyme 1 (BACE1), which serve as a rate limiting step in amyloid beta (Aβ) production altering the course of Alzheimer's disease. In addition, enzyme kinetics study and molecular docking were conducted to establish the inhibition type and structure activity relationship.

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