Open AccessDysregulation of Notch signaling related genes in oral lichen planus
Author(s) -
Nunthawan Nowwarote,
Thanaphum Osatha
Publication year - 2017
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2017.07.001
Subject(s) - notch signaling pathway , hes1 , oral lichen planus , jag1 , gene expression profiling , microarray , gene , biology , microarray analysis techniques , cancer research , gene expression , pathology , medicine , immunology , genetics
Objective: To investigate a dysregulation of Notch signaling in oral lichen planus (OLP) using public available microarray dataset.Methods: A mRNA expression profiling dataset from Gene Expression Omnibus was downloaded. Differential gene expression between OLP and normal oral epithelium was examined using NetworkAnalyst. The dysregulated genes related to Notch signaling were identified.Results: Thirteen genes in Notch signaling pathway were significantly differential expressed between OLP and normal epithelium. OLP samples significantly increased the mRNA levels of HEYL, APH1B, CNTN1 and PSEN2. Whilst, ITCH, HES1, TLE2, DLK2, DTX2, NOTCH3, JAG2, RFNG, and SPEN were downregulated in OLP groups.Conclusions: Notch signaling was dysregulated and may participate in pathophysiologic process in OLP