Open AccessEffects of interaction CdZn on serum-PSA level and prostate histology in rats
Author(s) -
Abdelkrim Berroukche,
Mohamed Terras,
Abdelrahmane Labani,
Hafsa Dellaoui,
Wassila Lansari
Publication year - 2017
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2016.12.012
Subject(s) - hyperplasia , prostate , cadmium chloride , histology , medicine , endocrinology , prostate specific antigen , antigen , epithelium , cadmium , pathology , chemistry , immunology , cancer , organic chemistry
Objective: To assess cadmium sulfate (CdSO4) and zinc chloride (ZnCl2) antagonist effects on the prostate specific antigen and prostatic cell organization in rats.Methods: The study included 40 adult male rats, divided into four groups: Group 1 (CdSO4), Group 2 (ZnCl2), Group 3 (CdSO4ZnCl2) and Group 4 (control). Animals were treated with CdSO4 and ZnCl2 at the same dose (15 mg/L) during 30 days.Results: It was showed a higher body weight and a lowering serum-prostate specific antigen concentration [(1.8 ± 0.6) ng/mL] in animals treated with CdSO4. CdSO4 induced a cyto-nuclear atypia, proliferative lesions, hyperplasia and precancerous foci in prostate tissue. Toxic effects of ZnCl2 were not recorded in this study.Conclusions: Protective role of zinc was exhibited against toxic effects of cadmium in prostate gland