Open AccessSecondary metabolites and their biological activities in Indonesian soft coral of the genus Lobophytum
Author(s) -
Masteria Yunovilsa Putra,
Tutik Murniasih,
Respati Tri Swasono,
Joko Tri Wibowo,
Annissa Nur Cahya Saputri,
Meilia Rahma Widhiana,
Irma S. Arlyza
Publication year - 2016
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2016.08.011
Subject(s) - chemistry , ethyl acetate , antioxidant , brine shrimp , cytotoxicity , bioassay , traditional medicine , butanol , chromatography , biochemistry , in vitro , biology , medicine , ethanol , genetics
ObjectiveTo investigate the antioxidant, antibacterial, antimalarial activities and cytotoxicity of the n-hexane, ethyl acetate, n-butanol, and aqueous fractions from a crude extract of Lobophytum sp.MethodsThis organism was collected from the Selayar Islands (South Sulawesi). The antioxidant activity was performed by the 1,1-diphenyl-2-picryl hydrazyl radical scavenging method. All fractions from the crude extract of Lobophytum sp. were examined for their cytotoxicity using the brine shrimp lethality bioassay and heme polymerization inhibitory activity assay for antimalarial activity.ResultsIt was found that the ethyl acetate, n-butanol and aqueous fractions exhibited heme polymerization inhibitory activity with IC50 values of 11.7, 14.3 and 12.0 μg/mL, respectively, while the n-butanol fraction showed moderate antioxidant activity and cytotoxicity with IC50 values of 150.00 and 92.74 μg/mL, respectively.ConclusionsThis study provides information on antioxidant, antibacterial and antimalarial activities as well as the cytotoxicity of all fractions from the crude extract of Lobophytum sp. This is a new report of antimalarial substances derived from Lobophytum sp