Open AccessIn vivo assessment of the toxic potential of Dissotis rotundifolia whole plant extract in Sprague–Dawley rats
Author(s) -
Charles Ansah,
Michael Buenor Adinortey,
Jerry Asiedu-Larbi,
Benjamin Aboagye,
Du-Bois Asante,
Alexander Kwadwo Nyarko
Publication year - 2016
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2016.04.010
Subject(s) - toxicity , in vivo , body weight , acute toxicity , pharmacology , hematology , traditional medicine , toxicology , chemistry , physiology , medicine , biology , microbiology and biotechnology
ObjectiveTo assess the toxic potential of Dissotis rotundifolia (D. rotundifolia) whole plant extract in Spraque–Dawley rats within a 2-week period of administration.MethodsMethanolic extract of D. rotundifolia was administered orally once daily at dose levels of 0, 100, 300 and 1000 mg/kg body weight for 14 days. Toxicity was assessed using mortality, clinical signs, body and organ weights, hematological indices, serum chemistry parameters and histopathological analyses.ResultsThere were no treatment-related mortalities or differences in clinical signs, hematology and serum biochemistry. This was confirmed by micrographs obtained from histopathological analysis.ConclusionsThe results obtained from the sub-acute toxicological assessment of D. rotundifolia extract suggest that the extract is non-toxic at doses up to 1000 mg/kg/day administered for a period of 14 days