Open AccessPlantago major treatment enhanced innate antioxidant activity in experimental acetaminophen toxicity
Author(s) -
Farida Hussan,
Rina Haryani Osman Basah,
Mohd Imran Yusof,
Nur Aqilah Kamaruddin,
Faizah Othman
Publication year - 2015
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2015.06.013
Subject(s) - malondialdehyde , superoxide dismutase , glutathione , acetaminophen , antioxidant , toxicity , pharmacology , lipid peroxidation , liver injury , acetylcysteine , medicine , chemistry , biochemistry , enzyme
Objective: To determine the effect of Plantago major (P. major) extract on the liver injury following acetaminophen (APAP) toxicity.Methods: The male Sprague Dawley rats (n = 38) were randomly divided into normal control (n = 6) and experiment (n = 32) groups. The latter was subdivided into four groups and induced with APAP (1000 mg/kg) per oral, followed by P. major extract and N-acetylcysteine orally to the respective groups for six days.Results: On the seventh day, the serum bilirubin, liver enzymes and tissue malondialdehyde were increased in APAP groups whereas the total protein in serum, tissue superoxide dismutase and glutathione levels were reduced. The plant extract treatment reduced the histological deteriorations such as aggregation of hepatocellular cords, formation of binucleated cells and vacuolisation of the cells with scanty cytoplasm. It also revealed significant reduction of malondialdehyde and increased level of superoxide dismutase and glutathione. The findings in the extract treated groups were comparable to the group treated with N-acetylcysteine.Conclusions: In conclusion, P. major can enhance innate antioxidant activity and ameliorate the APAP-induced liver injury