Open AccessEffects of Matricaria chamomilla extract on motor coordination impairment induced by scopolamine in rats
Author(s) -
Samira Asgharzade,
Zahra Rabiei,
Mahmoud Rafieian-Kopaei
Publication year - 2015
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2015.06.006
Subject(s) - matricaria chamomilla , motor coordination , scopolamine , rotarod performance test , chemistry , scopolamine hydrobromide , medicine , antioxidant , anesthesia , pharmacology , traditional medicine , motor activity , biochemistry , receptor , muscarinic acetylcholine receptor , psychiatry
ObjectiveTo evaluate the effect of ethanolic extract of chamomile on balance and motor learning in rats receiving scopolamine and intact rats.MethodsFourty-two rats were divided into 6 groups (n = 7). Control group received distilled water. Rats in Group 2 were given 1 mg/kg scopolamine. Groups 3 and 4 received chamomile extract 200 mg/kg and 500 mg/kg, respectively, and scopolamine simultaneously for 20 days. Intact groups (Groups 5 and 6) only received chamomile extract 200 mg/kg and 500 mg/kg, respectively. Motor coordination of rats was assessed with rotarod apparatus.ResultsAccording to the obtained results, compared with the control group, scopolamine significantly decreased time spent on rotarod performance (P < 0.001). Compared with scopolamine group, the strength and staying on rotarod apparatus in Group 3 significantly increased (P < 0.05). The results of this research showed that intact groups that received only chamomile extract at doses of 200 mg/kg and 500 mg/kg significantly increased time spent on rotarod, compared with scopolamine group (P < 0.001).ConclusionsThe results of this study indicated the high antioxidant property and protective effect of chamomile extract on motor coordination in the groups that received scopolamine