Open AccessA comparative UV−HPLC analysis of ten brands of ibuprofen tablets
Author(s) -
Sylvester Okhuelegbe Eraga,
Mathew I. Arhewoh,
Rosemary Ngozi Chibuogwu,
Magnus A. Iwuagwu
Publication year - 2015
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2015.06.005
Subject(s) - friability , ibuprofen , high performance liquid chromatography , chromatography , dissolution testing , active ingredient , medicine , chemistry , drug , pharmacology , biopharmaceutics classification system , first pass effect
Objective: To investigate the pharmaceutical equivalence of ten brands of ibuprofen tablets (400 mg) purchased from pharmacies in Benin City, Nigeria.Methods: The drug samples were subjected to uniformity of weight, crushing strength, friability, melting point, disintegration and dissolution tests following acceptable and official protocols. The ibuprofen content was determined using UV and high performance liquid chromatography method.Results: Crushing strength values of the drug samples ranged between 6 and 16 kp while the disintegration times were between 7.43 and 10.40 min (for uncoated tablets) and 3.25–37.32 min (for coated tablets). Friability values were less than 1% and the melting points of recrystallized ibuprofen from the samples ranged from 73.5 to 76.0 °C. The amount of ibuprofen released within 1 h ranged between 18% and 102% and two brands failed the content of active ingredient in the UV method of assay while all the brands passed the test using HPLC.Conclusions: Ibuprofen (400 mg) tablets marketed in Benin City, Nigeria vary in pharmaceutical quality