Open AccessAntidiabetic and antidiarrhoeal potentials of ethanolic extracts of aerial parts of Cynodon dactylon Pers.
Author(s) -
Md. Saidur Rahman,
Rasheda Akter,
Santosh Mazumdar,
Faridul Islam,
Nusrat Jahan Mouri,
Nemai Chandra Nandi,
Abu Sayeed Mohammad Mahmud
Publication year - 2015
Publication title -
asian pacific journal of tropical biomedicine/asian pacific journal of tropical biomedicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.507
H-Index - 61
eISSN - 2588-9222
pISSN - 2221-1691
DOI - 10.1016/j.apjtb.2015.04.011
Subject(s) - antidiarrhoeal , cynodon dactylon , traditional medicine , barium sulphate , medicine , castor oil , zoology , chemistry , biology , botany , biochemistry , radiochemistry
ObjectiveTo explore the antidiabetic and the antidiarrhoeal effects of ethanolic extracts of Cynodon dactylon Pers. aerial parts (EECA) in Wistar rats.MethodsTo assess the antidiabetic activity of EECA, oral glucose tolerance test (OGTT) model and alloxan induced diabetic test (AIDT) model were performed. The EECA was used at the doses of 2 g/kg, 1 g/kg and 500 mg/kg body weight in OGTT model and 1.5 g/kg was used for AIDT model. Castor oil-induced diarrhoeal model and gastrointestinal motility test with barium sulphate milk model were performed for evaluating the antidiarrhoeal effects at doses of 1 g/kg, 750 mg/kg respectively.ResultsThe dose 2 g/kg in OGTT and 1.5 g/kg in AIDT model blood glucose levels decreased significantly (P < 0.01) in Wistar rats that showed antidiabetic effect of EECA. After administration of EECA at the dose of 1 g/kg, the extract showed significant (P < 0.05) antidiarrhoeal activity in castor oil-induced diarrhoeal model. The results were also significant (P < 0.05) in barium sulphate milk model for the same dose by using above mentioned animals.ConclusionsIt is concluded that EECA contains both antidiabetic and the antidiarrhoeal properties