Open AccessTannic acid extracted from gallnut prevents post-weaning diarrhea and improves intestinal health of weaned piglets
Author(s) -
Yanyan Song,
Yong Luo,
Bing Yu,
Jun He,
Ping Zheng,
Xiangbing Mao,
Zhiqing Huang,
Junqiu Luo,
Yuheng Luo,
Hui Yan,
Quyuan Wang,
Huifen Wang,
Shuai Chen,
Jie Yu
Publication year - 2021
Publication title -
animal nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.356
H-Index - 28
eISSN - 2405-6545
pISSN - 2405-6383
DOI - 10.1016/j.aninu.2021.04.005
Subject(s) - diarrhea , jejunum , zoology , weaning , dry matter , duodenum , tannic acid , biology , medicine , biochemistry , botany
This experiment was conducted to evaluate the effects of different levels of tannic acid (TA) on growth performance, diarrhea rate, nutrient digestibility and intestinal health in weaned piglets. A total of 180 weaned piglets (Duroc × Landrace × Yorkshire, 24 d of age, initial average BW = 7.77 ± 0.17 kg) were allotted to 5 groups (6 pigs/pen and 6 replicates/group) in a randomized complete block design according to their gender and body weight. Piglets were fed a basal diet, or the basal diet supplemented with 0.05%, 0.1%, 0.2% or 0.4% TA for 28 d. The supplementary levels of TA in the diets were obtained by adding tannalbin containing 51% TA and 40.17% protein. The results showed that, compared with the CON group, dietary TA did not affect ADFI, ADG or F:G, and linearly reduced ( P < 0.01) the diarrhea rate and diarrhea index of piglets. There were no significant effects on apparent total tract digestibility (ATTD) in the 0.05%, 0.1% and 0.2% TA groups, while negative effects ( P < 0.05) on apparent digestibility of crude protein and gross energy were observed in the 0.4% TA group. In addition, the nutrient digestibility of dry matter, crude protein and gross energy linearly decreased ( P < 0.01) with the increase of TA dosage. Supplementation of TA increased ( P < 0.05) the villus height of the duodenum and jejunum, as well as increased ( P < 0.05) catalase (CAT) activity in serum. Dietary TA improved ( P < 0.05) the Bacillus counts in cecal digesta. Further, TA significantly improved ( P < 0.05) Bacillus counts and reduced ( P < 0.05) the Escherichia coli counts in colonic digesta. The concentration of acetic acid, propionic acid, butyric acid and isovaleric acid in cecal digesta were significantly increased ( P < 0.05). The mRNA expression level of zonula occludens-1 ( ZO-1 ), zonula occludens-2 ( ZO-2 ), and claudin-2 ( CLDN-2 ) in the jejunum were greater ( P < 0.05) in TA supplemented groups. The study showed that, compared to the control, TA prevented post-weaning diarrhea and improved intestinal health of weaned piglets, and the appropriate level of TA supplementation would be from 0.1% to 0.2%.