Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage | Zendy

Joshua A. Betts | Zendy; Mahdi Moradi Marjaneh | Zendy; Fares AlEjeh | Zendy; Yi Chieh Lim | Zendy; Wei Shi | Zendy; Haran Sivakumaran | Zendy; Romain Tropée | Zendy; AnnMarie Patch | Zendy; Michael B. Clark | Zendy; Nenad Bartoniček | Zendy; Adrian P. Wiegmans | Zendy; Kristine M. Hillman | Zendy; Susanne Kaufmann | Zendy; Amanda L. Bain | Zendy; Brian Gloss | Zendy; Joanna Crawford | Zendy; Stephen H. Kazakoff | Zendy; Shivangi Wani | Zendy; Shu Wen | Zendy; Bryan W. Day | Zendy; Andreas Möller | Zendy; Nicole Cloonan | Zendy; John V. Pearson | Zendy; Melissa A. Brown | Zendy; Tim R. Mercer | Zendy; Nicola Waddell | Zendy; Kum Kum Khanna | Zendy; Eloïse Dray | Zendy; Marcel E. Dinger | Zendy; Stacey L. Edwards | Zendy; Juliet D. French | Zendy

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Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage

Author(s) -

Joshua A. Betts,

Mahdi Moradi Marjaneh,

Fares AlEjeh,

Yi Chieh Lim,

Wei Shi,

Haran Sivakumaran,

Romain Tropée,

AnnMarie Patch,

Michael B. Clark,

Nenad Bartoniček,

Adrian P. Wiegmans,

Kristine M. Hillman,

Susanne Kaufmann,

Amanda L. Bain,

Brian Gloss,

Joanna Crawford,

Stephen H. Kazakoff,

Shivangi Wani,

Shu Wen,

Bryan W. Day,

Andreas Möller,

Nicole Cloonan,

John V. Pearson,

Melissa A. Brown,

Tim R. Mercer,

Nicola Waddell,

Kum Kum Khanna,

Eloïse Dray,

Marcel E. Dinger,

Stacey L. Edwards,

Juliet D. French

Publication year - 2017

Publication title -

the american journal of human genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.661

H-Index - 302

eISSN - 1537-6605

pISSN - 0002-9297

DOI - 10.1016/j.ajhg.2017.07.007

Subject(s) - dna damage , long non coding rna , breast cancer , biology , dna , cancer research , microrna , computational biology , cancer , rna , genetics , gene

Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence that the risk-associated SNPs are associated with reduced chromatin looping between the enhancer and the CUPID1 and CUPID2 bidirectional promoter. We further show that CUPID1 and CUPID2 are predominantly expressed in hormone-receptor-positive breast tumors and play a role in modulating pathway choice for the repair of double-strand breaks. These data reveal a mechanism for the involvement of this region in breast cancer.

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