Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors | Zendy

Ari AholaOlli | Zendy; Peter Würtz | Zendy; Aki S. Havulinna | Zendy; Kristiina Aalto | Zendy; Niina Pitkänen | Zendy; Terho Lehtimäki | Zendy; Mika Kähönen | Zendy; LeoPekka Lyytikäinen | Zendy; Emma Raitoharju | Zendy; Ilkka Seppälä | Zendy; AnttiPekka Sarin | Zendy; Samuli Ripatti | Zendy; Aarno Palotie | Zendy; Markus Perola | Zendy; Jorma Viikari | Zendy; Sirpa Jalkanen | Zendy; Mikael Maksimow | Zendy; Veikko Salomaa | Zendy; Marko Salmi | Zendy; Johannes Kettunen | Zendy; Olli T. Raitakari | Zendy

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Genome-wide Association Study Identifies 27 Loci Influencing Concentrations of Circulating Cytokines and Growth Factors

Author(s) -

Ari AholaOlli,

Peter Würtz,

Aki S. Havulinna,

Kristiina Aalto,

Niina Pitkänen,

Terho Lehtimäki,

Mika Kähönen,

LeoPekka Lyytikäinen,

Emma Raitoharju,

Ilkka Seppälä,

AnttiPekka Sarin,

Samuli Ripatti,

Aarno Palotie,

Markus Perola,

Jorma Viikari,

Sirpa Jalkanen,

Mikael Maksimow,

Veikko Salomaa,

Marko Salmi,

Johannes Kettunen,

Olli T. Raitakari

Publication year - 2016

Publication title -

the american journal of human genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.661

H-Index - 302

eISSN - 1537-6605

pISSN - 0002-9297

DOI - 10.1016/j.ajhg.2016.11.007

Subject(s) - genome wide association study , biology , quantitative trait locus , immunology , inflammation , disease , genetic association , expression quantitative trait loci , immune system , multiple sclerosis , ulcerative colitis , genetics , interleukin 10 , medicine , gene , single nucleotide polymorphism , genotype

Circulating cytokines and growth factors are regulators of inflammation and have been implicated in autoimmune and metabolic diseases. In this genome-wide association study (GWAS) of up to 8,293 Finns we identified 27 genome-widely significant loci (p < 1.2 × 10 -9 ) for one or more cytokines. Fifteen of the associated variants had expression quantitative trait loci in whole blood. We provide genetic instruments to clarify the causal roles of cytokine signaling and upstream inflammation in immune-related and other chronic diseases. We further link inflammatory markers with variants previously associated with autoimmune diseases such as Crohn disease, multiple sclerosis, and ulcerative colitis and hereby elucidate the molecular mechanisms underpinning these diseases and suggest potential drug targets.

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