Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases | Zendy

Hong Liu | Zendy; Astrid Irwanto | Zendy; Hongqing Tian | Zendy; Xi’an Fu | Zendy; Yongxiang Yu | Zendy; Gongqi Yu | Zendy; Hui-Qi Low | Zendy; Tongsheng Chu | Zendy; Yi Li | Zendy; Benqing Shi | Zendy; Mingfei Chen | Zendy; Yonghu Sun | Zendy; Chunying Yuan | Zendy; Nan Lü | Zendy; Jiabao You | Zendy; Fangfang Bao | Zendy; Jinghui Li | Zendy; Jian Liu | Zendy; Huaxu Liu | Zendy; Dianchang Liu | Zendy; Xiulu Yu | Zendy; Lin Zhang | Zendy; Qing Yang | Zendy; Na Wang | Zendy; Guiye Niu | Zendy; Shanshan Ma | Zendy; Yan Zhou | Zendy; Chuan Wang | Zendy; Shumin Chen | Zendy; Xuejun Zhang | Zendy; Jianjun Liu | Zendy; Furen Zhang | Zendy

Open Access

Identification of IL18RAP/IL18R1 and IL12B as Leprosy Risk Genes Demonstrates Shared Pathogenesis between Inflammation and Infectious Diseases

Author(s) -

Hong Liu,

Astrid Irwanto,

Hongqing Tian,

Xi’an Fu,

Yongxiang Yu,

Gongqi Yu,

Hui-Qi Low,

Tongsheng Chu,

Yi Li,

Benqing Shi,

Mingfei Chen,

Yonghu Sun,

Chunying Yuan,

Nan Lü,

Jiabao You,

Fangfang Bao,

Jinghui Li,

Jian Liu,

Huaxu Liu,

Dianchang Liu,

Xiulu Yu,

Lin Zhang,

Qing Yang,

Na Wang,

Guiye Niu,

Shanshan Ma,

Yan Zhou,

Chuan Wang,

Shumin Chen,

Xuejun Zhang,

Jianjun Liu,

Furen Zhang

Publication year - 2012

Publication title -

the american journal of human genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.661

H-Index - 302

eISSN - 1537-6605

pISSN - 0002-9297

DOI - 10.1016/j.ajhg.2012.09.010

Subject(s) - leprosy , immunology , disease , genetic predisposition , biology , odds ratio , pathogenesis , genetics , gene , medicine , pathology

Of eight leprosy susceptibility loci identified by genome-wide association studies, five have been implicated in Crohn disease, suggesting a common genetic fingerprint between leprosy and inflammatory bowel disease (IBD). Here, we conducted a multiple-stage genetic association study of 133 IBD susceptibility loci in multiple leprosy samples (totaling 4,971 leprosy cases and 5,503 controls) from a Chinese population and discovered two associations at rs2058660 on 2q12.1 (p = 4.57 × 10(-19); odds ratio [OR] = 1.30) and rs6871626 on 5q33.3 (p = 3.95 × 10(-18); OR = 0.75), implicating IL18RAP/IL18R1 and IL12B as susceptibility genes for leprosy. Our study reveals the important role of IL12/IL18-mediated transcriptional regulation of IFN-γ production in leprosy, and together with previous findings, it demonstrates the shared genetic susceptibility between infectious and inflammatory diseases.

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