A Genome-wide Association Study Reveals that Variants within the HLA Region Are Associated with Risk for Nonobstructive Azoospermia | Zendy

Han Zhao | Zendy; Jianfeng Xu | Zendy; Haobo Zhang | Zendy; Jielin Sun | Zendy; Yingpu Sun | Zendy; Zhong Wang | Zendy; Jiayin Liu | Zendy; Qiang Ding | Zendy; Shaoming Lu | Zendy; Rong Shi | Zendy; You Li | Zendy; Yingying Qin | Zendy; Xiaoming Zhao | Zendy; Xiaoling Lin | Zendy; Xiao Li | Zendy; Junjie Feng | Zendy; Li Wang | Zendy; Jeffrey M. Trent | Zendy; Chengyan Xu | Zendy; Ying Gao | Zendy; Bo Zhang | Zendy; Xuan Gao | Zendy; Jingmei Hu | Zendy; Hong Chen | Zendy; Guangyu Li | Zendy; Junzhao Zhao | Zendy; Shuhua Zou | Zendy; Hong Jiang | Zendy; Cuifang Hao | Zendy; Yueran Zhao | Zendy; Jing-Long Ma | Zendy; S. Lilly Zheng | Zendy; ZiJiang Chen | Zendy

Open Access

A Genome-wide Association Study Reveals that Variants within the HLA Region Are Associated with Risk for Nonobstructive Azoospermia

Author(s) -

Han Zhao,

Jianfeng Xu,

Haobo Zhang,

Jielin Sun,

Yingpu Sun,

Zhong Wang,

Jiayin Liu,

Qiang Ding,

Shaoming Lu,

Rong Shi,

You Li,

Yingying Qin,

Xiaoming Zhao,

Xiaoling Lin,

Xiao Li,

Junjie Feng,

Li Wang,

Jeffrey M. Trent,

Chengyan Xu,

Ying Gao,

Bo Zhang,

Xuan Gao,

Jingmei Hu,

Hong Chen,

Guangyu Li,

Junzhao Zhao,

Shuhua Zou,

Hong Jiang,

Cuifang Hao,

Yueran Zhao,

Jing-Long Ma,

S. Lilly Zheng,

ZiJiang Chen

Publication year - 2012

Publication title -

the american journal of human genetics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 6.661

H-Index - 302

eISSN - 1537-6605

pISSN - 0002-9297

DOI - 10.1016/j.ajhg.2012.04.001

Subject(s) - azoospermia , human leukocyte antigen , biology , genetics , single nucleotide polymorphism , odds ratio , genome wide association study , male infertility , gene , medicine , infertility , genotype , antigen , pregnancy

A genome-wide association study of Han Chinese subjects was conducted to identify genetic susceptibility loci for nonobstructive azoospermia (NOA). In the discovery stage, 802 azoospermia cases and 1,863 controls were screened for genetic variants in the genome. Promising SNPs were subsequently confirmed in two independent sets of subjects: 818 azoospermia cases and 1,755 controls from northern China, and 606 azoospermia cases and 958 controls from central and southern China. We detected variants at human leukocyte antigen (HLA) regions that were independently associated with NOA (HLA-DRA, rs3129878, p(combine) = 3.70 × 10(-16), odds ratio [OR] = 1.37; C6orf10 and BTNL2, rs498422, p(combine) = 2.43 × 10(-12), OR = 1.42). These findings provide additional insight into the pathogenesis of NOA.

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