Open AccessPseudomelanosis duodeni in a female adult with chronic renal failure
Author(s) -
Sun WeiChih,
Tsay FengWoei,
Lai KwokHung,
Hsu PingI,
Shih ChihAn
Publication year - 2014
Publication title -
advances in digestive medicine
Language(s) - English
Resource type - Journals
ISSN - 2351-9800
DOI - 10.1016/j.aidm.2013.12.002
Subject(s) - duodenum , lamina propria , medicine , gastroenterology , anemia , hemodialysis , stain , iron deficiency anemia , pathology , gastrointestinal bleeding , melena , staining , epithelium
Summary Pseudomelanosis duodeni is a rare endoscopic finding that manifests as dark speckled spots in the duodenum. It is considered a benign condition and is associated with certain diseases and the use of certain medications. This study reports a case of a 74‐year‐old woman, with end‐stage renal disease under maintenance hemodialysis, hypertension under regular medical control, iron deficiency anemia under oral iron supplement, and progressive anemia with suspicious occult gastrointestinal bleeding. Upper gastrointestinal endoscopy revealed multiple tiny brownish‐black pigmentation throughout the proximal second portion of the duodenum. The histopathological examination showed pigment‐laden macrophages with positive iron stain and negative melanin stain in the lamina propria of the mucosal villi.