Inhibir la contractilidad sin provocar necrosis: ¿sería útil en miocardiopatía hipertrófica? Modelo experimental de administración intramiocárdica de toxina botulínica y de wortmanina | Zendy

FranciscoJavier Roldán | Zendy; Natalia Pavón | Zendy; Faustino Gálvez-Pérez | Zendy; Jesús VargasBarrón | Zendy

Open Access

Inhibir la contractilidad sin provocar necrosis: ¿sería útil en miocardiopatía hipertrófica? Modelo experimental de administración intramiocárdica de toxina botulínica y de wortmanina

Author(s) -

FranciscoJavier Roldán,

Natalia Pavón,

Faustino Gálvez-Pérez,

Jesús VargasBarrón

Publication year - 2012

Publication title -

archivos de cardiología de méxico

Language(s) - Spanish

Resource type - Journals

eISSN - 1405-9940

pISSN - 1665-1731

DOI - 10.1016/j.acmx.2012.06.007

Subject(s) - hypertrophic cardiomyopathy , medicine , wortmannin , necrosis , apoptosis , endocrinology , chemistry , pi3k/akt/mtor pathway , biochemistry

The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and wortmannin directly in the myocardium are disclosed.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research