Open AccessInhibir la contractilidad sin provocar necrosis: ¿sería útil en miocardiopatía hipertrófica? Modelo experimental de administración intramiocárdica de toxina botulínica y de wortmanina
Author(s) -
Francisco Javier Roldán-Gómez,
Natalia Pavón-Martínez,
Faustino Gálvez-Pérez,
Jesús VargasBarrón
Publication year - 2012
Publication title -
archivos de cardiología de méxico
Language(s) - Spanish
Resource type - Journals
eISSN - 1405-9940
pISSN - 1665-1731
DOI - 10.1016/j.acmx.2012.06.007
Subject(s) - hypertrophic cardiomyopathy , medicine , wortmannin , necrosis , apoptosis , endocrinology , chemistry , pi3k/akt/mtor pathway , biochemistry
The purpose of this paper is to introduce a new idea: local inhibition of contractility without necrosis. It's potential usefulness in hypertrophic cardiomyopathy treatment is discussed and 2 pharmacological models, administrating botulinum toxin and wortmannin directly in the myocardium are disclosed.