Open AccessA new pharmacological role for thalidomide: Attenuation of morphine-induced tolerance in rats
Author(s) -
Kambiz Hassanzadeh,
Bashir Khodadadi,
Mohammad Raman Moloudi,
Heresh Amini,
Mohammad Reza Rahmani,
Esmael Izadpanah
Publication year - 2016
Publication title -
acta anaesthesiologica taiwanica
Language(s) - English
Resource type - Journals
eISSN - 1875-4597
pISSN - 1875-452X
DOI - 10.1016/j.aat.2016.06.002
Subject(s) - thalidomide , medicine , licking , morphine , ed50 , pharmacology , nociception , analgesic , anesthesia , multiple myeloma , receptor
Tolerance to the analgesic effect is the main side effect of chronic administration of opioids. Several drugs have been studied to try to find agents to prevent the development of this phenomenon. In the present study we aimed to evaluate the effect of thalidomide on morphine-induced tolerance to the analgesic effect.
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