Pharmacogenomics for personalized pain medicine | Zendy

TaiMing Ko | Zendy; ChihShung Wong | Zendy; Jer-Yuarn Wu | Zendy; Yuan-Tsong Chen | Zendy

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Pharmacogenomics for personalized pain medicine

Author(s) -

TaiMing Ko,

ChihShung Wong,

Jer-Yuarn Wu,

Yuan-Tsong Chen

Publication year - 2016

Publication title -

acta anaesthesiologica taiwanica

Language(s) - English

Resource type - Journals

eISSN - 1875-4597

pISSN - 1875-452X

DOI - 10.1016/j.aat.2016.02.001

Subject(s) - pharmacogenomics , medicine , pharmacogenetics , drug , context (archaeology) , analgesic , pain medicine , neuropathic pain , personalized medicine , intensive care medicine , adverse effect , chronic pain , intervention (counseling) , bioinformatics , pharmacology , psychiatry , anesthesiology , gene , paleontology , biochemistry , chemistry , biology , genotype

Pharmacogenomics aims to unravel the way that human genetic variation affects drug efficacy and toxicity. Genome-wide association studies and candidate gene findings suggest that genetic approaches may help choose the most appropriate drug and dosage while preventing adverse drug reactions (ADRs). Pain is an unpleasant feeling that usually results from tissue damage. The management of different types of pain (acute, chronic, inflammatory, neuropathic, or cancer) is challenging. Currently, drug intervention is the first-line therapy for resolving pain. However, differences in drug efficacy between individuals are common with pain medications. Moreover, some patients experience ADRs after being treated with specific pain drugs. This review discusses the use of drugs for pain management in the context of the recent pharmacogenomic studies on ADRs and drug efficacy.

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