The effect of propofol and sevoflurane on antioxidants and proinflammatory cytokines in a porcine ischemia–reperfusion model | Zendy

Hung-Tsung Hsiao | Zendy; HungTsung Wu | Zendy; Pei-Chi Huang | Zendy; Yu-Chuang Tsai | Zendy; YenChin Liu | Zendy

Open Access

The effect of propofol and sevoflurane on antioxidants and proinflammatory cytokines in a porcine ischemia–reperfusion model

Author(s) -

Hung-Tsung Hsiao,

HungTsung Wu,

Pei-Chi Huang,

Yu-Chuang Tsai,

YenChin Liu

Publication year - 2015

Publication title -

acta anaesthesiologica taiwanica

Language(s) - English

Resource type - Journals

eISSN - 1875-4597

pISSN - 1875-452X

DOI - 10.1016/j.aat.2015.11.002

Subject(s) - sevoflurane , proinflammatory cytokine , medicine , propofol , lipid peroxidation , in vivo , oxidative stress , thiobarbituric acid , pharmacology , tumor necrosis factor alpha , ischemia , reactive oxygen species , reperfusion injury , anesthesia , immunology , inflammation , biochemistry , chemistry , biology , microbiology and biotechnology

Ischemia-reperfusion (IR) features massive oxidative stress of tissues and cytokine response. Propofol and sevoflurane, both of which are commonly used anesthetics, are thought to have different antioxidant activities. The aim of this study is to delineate the influence of these two drugs on the production of free radicals and proinflammatory cytokines in IR conditions via in vitro and in vivo models.

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