Levobupivacaine differentially suppresses platelet aggregation by modulating calcium release in a dose-dependent manner | Zendy

Jiin-Tarng Liou | Zendy; Chih-Chieh Mao | Zendy; Fu-Chao Liu | Zendy; Huan-Tang Lin | Zendy; LiMan Hung | Zendy; ChangHui Liao | Zendy; YuanJi Day | Zendy

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Levobupivacaine differentially suppresses platelet aggregation by modulating calcium release in a dose-dependent manner

Author(s) -

Jiin-Tarng Liou,

Chih-Chieh Mao,

Fu-Chao Liu,

Huan-Tang Lin,

LiMan Hung,

ChangHui Liao,

YuanJi Day

Publication year - 2012

Publication title -

acta anaesthesiologica taiwanica

Language(s) - English

Resource type - Journals

eISSN - 1875-4597

pISSN - 1875-452X

DOI - 10.1016/j.aat.2012.07.001

Subject(s) - platelet , levobupivacaine , medicine , pharmacology , platelet activation , thromboxane a2 , protein kinase b , signal transduction , chemistry , biochemistry , bupivacaine

Levobupivacaine, an amide local anesthetic widely used in regional anesthesia, is reported in recent studies that it is a potent inhibitor of platelet functions. However, the concentrations of levobupivacaine were limitedly estimated in these reports. Additionally, the mechanisms by which it affects platelet function and blood coagulation is still not entirely known. The purpose of this study was to further investigate its effects on platelet function and the possible signaling mechanisms under various concentrations of levobupivacaine.

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