Open Access
Ketotherapeutics for neurodegenerative diseases.
Author(s) -
Nicholas G Norwitz,
Javier Gilbert Jaramillo,
Kieran Clarke,
Adrian Soto
Publication year - 2020
Publication title -
international review of neurobiology
Language(s) - English
Resource type - Journals
eISSN - 2162-5514
DOI - 10.1016/bs.irn.2020.02.003
Alzheimer's disease (AD) and Parkinson's disease (PD) are, respectively, the most prevalent and fastest growing neurodegenerative diseases worldwide. The former is primarily characterized by memory loss and the latter by the motor symptoms of tremor and bradykinesia. Both AD and PD are progressive diseases that share several key underlying mitochondrial, inflammatory, and other metabolic pathologies. This review will detail how these pathologies intersect with ketone body metabolism and signaling, and how ketone bodies, particularly d-β-hydroxybutyrate (βHB), may serve as a potential adjunctive nutritional therapy for two of the world's most devastating conditions.