Open AccessThe Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer.
Author(s) -
Sara Karaki,
Claudia Andrieu,
Hajer Ziouziou,
Palma Rocchi
Publication year - 2015
Publication title -
advances in protein chemistry and structural biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.262
H-Index - 72
pISSN - 1876-1623
DOI - 10.1016/bs.apcsb.2015.09.001
Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as targets for potential anticancer drugs. Cap-dependent translation starts when eIF4E binds to mRNA cap domain. This review will present eIF4E's structure and functions. It will also expose the use of eIF4E as a therapeutic target in cancer.