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231 The effect of toluene on hypothalamic regulation of reproductive function in female rats
Author(s) -
Korenevsky A.V.,
Arutjunyan A.V.,
Stepanov M.G.,
Prokopenko V.M.,
Oparina T.I.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80420-5
Subject(s) - citation , library science , medicine , psychology , computer science
The inhalation effect of toluene monthly dosed 500 mg/m3 on both biogenic amines and their metabolites content and free radical oxidation (FRO) intensity in hypothalamic structures accountable for gonadoliberin synthesis and secretion (preoptic area and medial eminence) has been studied. The most of investigated parameters are shown to undergo circadian variations which are disturbed by toluene. The dopamine morning content in the structures mentioned abovc is significantly higher than its evening level. The same tendency occurs in the case of serotonine. There has been revealed dependence of biogenic amines and their metabolites contents on an estrous cycle stage that is decreased by xenibiotic effect. The circadian changes of FRO intensities and their discoordination in the chronic esperiment has been observed. The stimulation of FRO processes in rats treated by toluene has been accompanied by enhancement of lipids perosidauon in initial stages. The data obtained show that the reproductive system response to the effect of toluene and perhaps of other neurotropic xenobiotics is the disturbance of hypothalamic regulation of circadian rhythms.