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209 Development of synaptic plasticity in the cerebral ganglion of Aplysia
Author(s) -
Fredman S.M.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80398-4
Subject(s) - aplysia , neuroscience , citation , synaptic plasticity , psychology , library science , computer science , biology , receptor , biochemistry
In previous studies we demonstrated that F3, a GPIanchored molecule of the immunoglobulin (Ig) super family made of 6 Ig-like domains and 4 FNIII repeats, can play a role in cell adhesion and control of neurite outgrowth. We already showed that F3 either presented as a component of the surface of transfected cells or in soluble form stimulated neurite outgrowth of sensory neurons. We will show that F3 or F3-Ig domains expressed on a monolayer of transfected cells induce a strong reduction of neurite outgrowth of isolated cerebellar neurons together with a high fasciculation of neurites when the same cells are grown as reaggregates. A recombinant F3Fc chimeric molecule compraising its Ig-like domains used as a coated substrate has the same effect on neurite fasciculation but not its soluble form. Thus F3 can exert stimulating or inhibitory effects on neurite outgrowth depending on the neurons tested. Such functional diversity can be mediated by neuronal cell-type specific receptors; alternatively, it might result from the triggering of different transducing pathways.