Premium
198 Further evidence for nuclear translocation of retrogradely transported GTP‐binding protein G zα
Author(s) -
Johanson S.O.,
Heydon K.,
Bartlett S.E.,
Hendry I.A.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80387-x
Subject(s) - citation , gtp' , library science , computer science , physics , nuclear magnetic resonance , enzyme
The seizure susceptibility chanses markedly during the maturation of Ihe neocortex. Accordrn: ID DUI PI-evious studies a critical period is detectable around the second week after birth 111 rat pups. In this serves of experiments we lnvesigated the changes of the effects of glutamate antagonists under normal conditions and during seizure activity evoked by alteration of the composition of the perfusion solution. The effects of the NMDA antaxonlsr APV and the noesNMDA antagonnr GYKI 5378 3 Ywe mvesrlg,ued lil coronal sections of neocor~cx of rats of differ-en\ a:ei, losing conventional !nxroelectrophyslological techniques The mhlbirory effect of the antagonists was studied on the EPSPs evoked by stnnulation of corpus callosum, in normal perfusion solntioll. In Mg”-free solution the pattern of epileptic activity and the effect of the NMDA and non-NMDA antagonist were invehligated on the spontaneous acuvtcy and electrically evoked responses The panem of the spontaneous acilvjly m ME”-free medn~m was different in rhe two age groups, while the effect of the nonNMDA antagonist did not differ significantly in slices prepared from young or adult rats. In contrast, the inhibition by APV was more pronounced in the two-week-old animals, than in adults. COMPARATIVE ANALYSIS OF GLUTAMATE DECARBOXYLASES IN VERTEBRATES