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189 Susceptibility of neonatal brain astrocytes to retroviral infection following ethanol exposure
Author(s) -
Tewari S.,
Yazdi J.,
Vera J.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80378-9
Subject(s) - citation , glioblastoma , library science , medicine , computer science , cancer research
‘II&e effects of prenatal ochratoxin A (a mycotoxin) treatment and X-irradiation on the developing neurons and synapses in the cerebral cortex were examined quantitatively using the unfolding method. Mice were injected i.p with 3mg OA/kg on day 10 of gestation, and their offspring were killed at 6 weeks of age. Rats were X-inadiated (1.0 Gy) on day 1S of gestation, and their offspring were killed at 7 weeks of age. Animals were perfused under anesthesia, and right somatosensory (SC) and visual (VC) cmlcx were dissected out, postfixed, and embedded in Epon. OAtreatment or X-irradiation resulted in severe microccphaly. Brain weight was reduced significantly. Significani decrease in cortical thickness was seen in SC (30%) and VC (18%) of OA-treated mice, and SC (25%) and VC (16%) of X-irradiated rats. In OAtreated mice, there was a significant increase (39%) in the numerical density of neurons, but no significant changes were observed in the numerical density of synapses. Synapse-to-neuron ratios showed a significant decrease (28%) in SC. On the other hand, X-irradiation rats showed no significant changes in synapseto-neuron ratios. This suggested that the dierence in the effa of OA and X-irradiation on Ihe developing cortical neurons mighi arise from the difference of nemotoxicity.