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177 The effects of citalopram administration on spatial discrimination, reversal learning and extinction in the rat
Author(s) -
Naghdi N.,
Majlessi N.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80366-2
Subject(s) - citalopram , extinction (optical mineralogy) , citation , administration (probate law) , library science , psychology , computer science , political science , neuroscience , biology , law , paleontology , hippocampus , antidepressant
In the present study the effect of dopaminergic receptor antagonist on the spatial descrimination task in an &arm radial maze as well as on the rhytmic slow activity (RSA) of the hippocampus was investigated. A pair of electrodes were implanted in the dorsal hippocampus of rats and after a week of recovery they were trained in an g-arm radial maze apparatus and RSA was recorded every day before training. The frequency of RSA and also the ratio of RSA to non-RSA were increased by the learning procedure. Injection of Dl antagonist SCH23390 (0.05 mg/kg i.p.), given on days 1,4,7 and 10, impaired acquisition and also decreased the frequency of RSA wawes and the RSA to non-RSA ratio on the injection days. The effect of postsynaptic D2 antagonist sulpiride (50 mg/kg i.p.) was the same as DI antagonist, but presynaptic D2 antagonist sulpinde (25 m&g i.p.) did not have any effect. The concurrent administration of postsynaptic Dl and D2 antagonists produced a synergistic effect in both decreasing acquisition and RSA wawes. Our data suggest that both postsynaptic Dl and D2 receptors have a role in the rhythmic slow activity of the hippocampus and in spatial learning.