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176 Involvement of monosialoganglioside gm1 on spatial learning and long‐term potentiation in rats
Author(s) -
Moazedi A.A.,
Motamedi F.,
Semnanian S.,
Hosseine A.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80365-0
Subject(s) - citation , long term potentiation , library science , term (time) , psychology , computer science , information retrieval , medicine , physics , receptor , quantum mechanics
In the present study the effect of dopaminergic receptor antagonist on the spatial descrimination task in an &arm radial maze as well as on the rhytmic slow activity (RSA) of the hippocampus was investigated. A pair of electrodes were implanted in the dorsal hippocampus of rats and after a week of recovery they were trained in an g-arm radial maze apparatus and RSA was recorded every day before training. The frequency of RSA and also the ratio of RSA to non-RSA were increased by the learning procedure. Injection of Dl antagonist SCH23390 (0.05 mg/kg i.p.), given on days 1,4,7 and 10, impaired acquisition and also decreased the frequency of RSA wawes and the RSA to non-RSA ratio on the injection days. The effect of postsynaptic D2 antagonist sulpiride (50 mg/kg i.p.) was the same as DI antagonist, but presynaptic D2 antagonist sulpinde (25 m&g i.p.) did not have any effect. The concurrent administration of postsynaptic Dl and D2 antagonists produced a synergistic effect in both decreasing acquisition and RSA wawes. Our data suggest that both postsynaptic Dl and D2 receptors have a role in the rhythmic slow activity of the hippocampus and in spatial learning.