Premium
174 Spatial learning impairment following injection of 6‐ohda and ascorbic acid to the ventral tegmental area
Author(s) -
Esmaili M.H.,
Motamedi F.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80363-7
Subject(s) - ventral tegmental area , ascorbic acid , citation , spatial learning , library science , psychology , neuroscience , computer science , biology , horticulture , dopamine , dopaminergic , hippocampus
Glucocorticoid hormone induced DNA internucleosomal fragmentation first has been shown by Zakhatyan R.A. and Pogosian R.G. (Proc Acad. Sci Arm. SSR v.LXVII, 12, 110-113. 1978). later these results were contirmcd by Willie AH (Nature 284, 555-556; 1980). The phenomenon that is the most characteristic biochemical marker of the programmed cell death, apoptosis In the present work we show that double stranded RNA (G:C) which is the ligand of the acetylcholine receptor in brain cortex cells (Zakharyan R.A., Bakuntz K.S , Skobelcva N S.. Neyrokhimia, 8, 34-38. 1989) of the muscarine type Ml (Zakharyan R.A QLT/ congress. ENA/EBBS-BRA. Cambridge, 1991) inducts chromatin DNA intemucleosomal fragmentation. programmed cell death in rat thymocyte cells. The effect is dose dependent and is more strikmg during the combined desamethazone and dsRNA action The mechanism of anticancer and antivirus dsRNA action as a ligand for acetylcholine receptor of bram cortex cells is mediated by induction of the programmed cell death. apoptosis. EFFECTS OF MONOCLONAL ANTIBODIES ON THE DEVELOPMENT OF RAT HIPPOCAME’US IN SLICE CULTURE.