Premium
147 Cytokine effects on axotomyinduced glial reactions in transgenic mice
Author(s) -
Jensen M.B.,
Renno T.,
Peterson A.C.,
Owens T.,
Finsen B.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80336-4
Subject(s) - citation , glioblastoma , library science , computer science , medicine , cancer research
Restorative processes were studied in visual cortex (area 17) cells, following cortical lesions made at various postnatal ages. The experimental groups were kittens operated at 1 (7 cats, 269 cells), 2 (6 cats, 504 cells), 4 (4 cats, 332 cells), 8 (5 cats, 437 cells) and 12 (7 cats, 487 cells) weeks of age. 14 adult cats (429 cells) were used as normal controls. An incision was made in one hemisphere, between the sagittal line and the lateral or postlateral sulcus. Single cells were recorded in the pmand post-lesion regions followutg anesthesia and paralysis, using microelectrodcs. Receptive fields were mapped, orientation and direction selectivity esamined, PSTH’s computed and electrode tracks histologically contirmed. The responsiveness was significantly higher (P