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120 Dexmedetomidine, diazepam and propranolol in the treatment of ethanol withdrawal symptoms in rat
Author(s) -
A. Kinnunen
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80310-8
Subject(s) - dexmedetomidine , propranolol , diazepam , citation , medicine , anesthesia , psychology , computer science , library science , sedation
A transient histamine-containing neuronal system is found m rat and mouse brain during the second half of embryonic development, whereas the adult-like tuberomammillary histaminergic system develops later. Signal transduction pathways of the early systems have not been characterized. H, receptor has been implicated in development, but its expression has not been studied. RT-PCR and rn situ hybridization methods were used to study the expression of H, receptor in fetal and postnatal rat brain Expression of the recepior was iietrcted on embryonai day El6, which was the first day studied with RT-PCR In siru hybridization with an oligonucleotide probe indicated that receptor mRNA at this rime, and during the rest of the fetal period, was highly concentrated in the CNS. High expression was characteristic for the whole CNS from developing forebain to the spinal cord. On day El 8, the expression was high in the neuroepithelium throughout the brain and in e.g cortical plate. During postanaral development. a more restricted adult-like expression paliern gradually developed In adult brain, high expression was seen in the olfactory tuber&, hippocampus, amygdala, and reticular thalamic nucleus. Hypothalamic nuclei, cerebral cortex and solitary tract nucleus displayed moderate expression. H, receptor is expressed early and histamine may modulate early brain functions through H, mechanisms.