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82 Exposure to nicotine during a defi‐ ned period in neonatal life induces permanent changes in brain nicotinic receptors and response to nicotine in adult mice
Author(s) -
Eriksson P.,
Ankarberg E.,
Fredriksson A.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80277-2
Subject(s) - nicotine , period (music) , nicotinic agonist , neuroscience , citation , medicine , psychology , receptor , library science , art , computer science , aesthetics
Neuronal nicotinic receptors belong to the ligand-gated ion channels family: up to now 8a (a2-a9) and 3B (B2-84) subunits have been cloned. Biophysical and pharmacological properties of nicotinic receptors in brain depend on their subunit composition, furthermore the different nicotinic subunits have a discrete hxalization in brain that is also different among the species. We study the brain distribution of subunits in adult animals and during the development by in situ mRNA hybridization and (3H)-LNicotine and (125 I)a-bungarotoxin binding. The distribution of nicotinic subunits in humans, monkey and rat will be described and compared. We will focus on the expression during the development of a4 and 82 subunits in rat brain and of a7 and a8 subunits in chick brain. The results show that there is a specific pattcm of expression during development for the different subunits and for the different brain areas studied (especially in the thalamus), and that a4 and 02 subunits am independently regulated. Therefore, it is very important to study the mechanisms of regulation of the expression of the nicotinic subunit genes. We will report data concerning the human a3 promoter and the acttvity of its components. P. Eriksson, E. Ankarberg and A. Fredriksson, Dept. of Environ Toxicol., Uppsala University, S-752 36 Uppsala, Sweden.