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74 The growing family of eph receptors and their function in brain development
Author(s) -
Klein Rüdiger,
Orioli Donata,
Henkcmeyer Mark,
Pawson Tony
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80269-3
Subject(s) - erythropoietin producing hepatocellular (eph) receptor , eph receptor a2 , neuroscience , receptor , brain development , function (biology) , biology , genetics , receptor tyrosine kinase
Development of the visual system has long served as a useful model to investigate critical cellular interactions w&h underlie and culminate in stereotypx connectivity of the nervous system. Rttinotectal systems from numerous species exhibit guidance components involved io early navigation of retinal axons across their target nuclei. Botb avian and rodent systems display repulsive guidance material in their posterior target regions, however, differences in the initml precision of their topography in viva suggest distinct guidance componeats may be involved. To elucidate cellular cues which could account for differences in these systems, we established for both chick and mouse co-cultures of retinae and their respective target cells. Indicating similar repellent activity in these hvo systems, contact with neurons from posterior tecta or superior colliculus cause growth cones from temporal retinae to collapse and retract. Differences between the two systems can be attributed to componeots on glial cells which do not induce growth cone collapse and retraction. Generally, mouse plia appear more permissive than those in chick. Together these dau Indicate that m early development key differences between tie avian retinotectal and the rodent retinocollicular systems may lie in the guidance material expressed selectively by their respective glial cells. This work was performed while RWD held a National Research CouncilNICILD/NIII Research Associateship.