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38 Glial ecm in neural development and plasticity
Author(s) -
Faissner A.,
Scholze A.,
Götz B.,
Joester A.,
Schnädelbach O.,
Wigger F.,
Schütte K.,
Clement A.
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80233-4
Subject(s) - citation , computer science , library science , artificial intelligence
CommissuraJ sons pioneer a clrcumferenbal pathway to the floor plate at the venual midline of the spinal cord. Floor plate cells secrete a diffusible factor that attracts these axons tn VIITO. suggesting that then ventral growth IS directed by cbemotropism We have purified from embryomc chick bram two proteins. netnn -I and netrin-2. that each mimic the activity of the iloor plate Cloning of cDNAs encoding the netnns shows lhat they are vertebrate bomologues of UNC-6, a lamlmn-related protein required for the circumferenbal dorsal and ventral rmgration of cells and i~xons in the nematode C. elegant. The netnnI gene 1s expressed by floor plate cells, and beterologous cells secreung recombinant netrin1 munic the long-range cbemotropic activity of floor plate cells Moreover, axons that grow dorsally away from the floor plate are repelled by netrin-1. Thus. nelnn-1 is a bifunctional guidance cue that may serve to attract some axons LO the floor plate while steering others away Enamma(lon of the trajectories of conunissural axons in race lackmg nebin-l imhcates that netnn-1 is required in V~L’O for the growth of most commissnral axons to the floor plate. Netinis also required 1~1 ~110 for the proper development of other commissures such as the hppocampal c~mm~~urc and rhe corpus callosum Faissner, A., A. Scholze, B. G&z, A. Joester, 0. Schngdelbach, F. Wigger, K. Schiitte, and A. Clement. Department of Neurobiology, INF 364, D-69120 Heidelberg, FRG.