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34 The role of signalling through eph receptors in patterning the zebrafish neural plate
Author(s) -
Holder Nigel,
Brennan Caroline,
Cooke Julie,
Durbin Lindsay,
Xu Qiling
Publication year - 1996
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/0736-5748(96)80229-2
Subject(s) - erythropoietin producing hepatocellular (eph) receptor , associate editor , zebrafish , citation , editorial board , library science , ephrin , cognitive science , neuroscience , art history , art , receptor , biology , computer science , psychology , genetics , gene , receptor tyrosine kinase
In Drosophila, commitment to a neural face is cantrolled by the Delta-Notch-E(spt) cell-cell signallimg pathway. which mediates lateral inhibilion. In both CNS and PNS, this Serves to single out individual cells for a neural fate and to prevent their neighbours from becoming committed in the same way. Does the same mechanism control neurogenesis similarly in vertebrates? Multiple vertebrate homologues of the genes coding for the receptor Notch, its ligands Delta and Serrate, and its downstream effcctors of the E(spl) class have been identiied. AlI of these are expressed during neurogenesis both in the CNS and in the PNS, in pattern suggesting tiat they do Indeed have a universal role in controlling neurogenesls. both in the CNS and in the PNS, and during late as well as early stages. This view is supported by functional tests in which we have ectopicatly erpmd Delta-l or the antimorphic construct Delta-lSTU, using either mRNA Injection into early blastomeres in Xenopl~s and zebraf=h. or infection with a retrovual vector in the chick. There are, however. some features that conuas~ with Drosophila; but in these respects there are also vtiations among verlebrates themselves. For example, where% in the CNS of Xenopus and chick the neural cells transiently expressing Delta-l are postmitotic nascent neurons, in neurogenesis in the otic placode they are proliferative neumbla.sfs as in Drosophila.